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SB 452533
SB 452533 is an antagonist of the vanilloid receptor 1(pKb: 7.8).
Catalog No. T23322Cas No. 459429-39-1
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Purity:98.52%
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SB 452533
Catalog No. T23322Cas No. 459429-39-1
SB 452533 is an antagonist of the vanilloid receptor 1(pKb: 7.8).
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $35 | In Stock | |
| 5 mg | $58 | In Stock | |
| 10 mg | $98 | In Stock | |
| 25 mg | $193 | In Stock | |
| 50 mg | $298 | In Stock | |
| 100 mg | $433 | In Stock | |
| 200 mg | $616 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $77 | In Stock |
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CitedProduct Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | SB 452533 is an antagonist of the vanilloid receptor 1(pKb: 7.8). |
| Targets&IC50 | TRPV1:7.8(pKb) |
| In vitro | SB 452533 significantly reduced Capsaicin-induced phosphorylation of AMPK and CAMKK2[1]. |
| In vivo | Small dose Cap significantly reduced bleomycin-induced pulmonary fibrosis in mice and obviously reversed alveolar epithelial cells epithelial-mesenchymal transition (EMT) (the expression of E-cadherin and ZO-1 were increased(P＜0.05 or P＜0.01)and the expression of α-SMA and Vimentin were decreased (P＜0.05 or P＜0.01) after drugs treatment for 21 day, concomitantly with the increase the expressions of TRPV1 and CGRP (P＜0.05 or P＜0.01), and inhibiting ERK1/2 phosphorylation and eIF3a expression (P＜0.05 or P＜0.01). These effects of small dose Cap were abolished in the presence of TRPV1 receptor antagonist SB 452533[2]. |
| Molecular Weight | 376.29 |
| Formula | C18H22BrN3O |
| Cas No. | 459429-39-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: < 1 mg/mL (insoluble or slightly soluble) DMSO: 60 mg/mL (159.45 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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